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Pharmacological effects of carnosic acid

(1) Antibacterial effect studies have shown that carnosic acid has different degrees of inhibitory effect on Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Hansenula, and can be used as food preservatives.

(2) Antioxidative effect Carnosic acid has good free radical scavenging and antioxidant effects. Its DPPH, ABTS free radical scavenging ability and iron reduction antioxidant ability are stronger than VE, slightly weaker than synthetic antioxidant TBHQ; its reducing ability is stronger than VE and TBHQ. Carnosic acid is fat-soluble and can effectively inhibit the formation of peroxides and the decomposition of polyene fatty acids in oils, thereby extending the shelf life of oils. In addition, the study found that carnosic acid can effectively scavenge oxygen free radicals in mouse liver cells, reduce the production of lipid peroxides, thereby stabilizing the cell membrane; carnosic acid can also inhibit the oxidation reaction of low-density lipoprotein Chemicalbook white, which can Effectively prevent the occurrence of atherosclerosis.

(3) Other effects Studies have found that carnosic acid has an inhibitory effect on the proliferation of HL-60 cells, and is expected to become a new drug for the treatment of hematological malignancies, for the treatment of cardiovascular diseases and anti-cancer. Kaloustian et al. introduced that carnosic acid and other rosemary extracts have certain therapeutic effects on heart disease and respiratory diseases, have antibacterial effects, and can also inhibit HIV infection. Ninomiya et al. reported that carnosic acid and other rosemary extracts can not only control human body weight by effectively regulating fat absorption, so as to achieve the purpose of losing weight, but also can treat inflammation, treat sore throat, treat indigestion, and prevent old age. Dementia, treating diabetes, and promoting the production of nerve growth factors.

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