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Pharmacological effects of rosmarinic acid

1 Antioxidant effect

Rosmarinic acid has a strong scavenging activity of free radicals in the body and an antioxidant effect. Studies have shown that its mechanism of action is: rosmarinic acid competes with unsaturated fatty acids to combine with lipid peroxy groups to terminate the chain reaction of lipid peroxidation and reduce the rate of lipid peroxidation, while rosmarinic acid is oxidized to Quinoid; marinic acid inhibits neutrophil respiratory burst and inhibits lysosome release by reducing intracellular calcium ion concentration; inhibits endothelial cell-mediated low-density lipoprotein oxidation. The antioxidant effect of rosmarinic acid is related to its structure. Studies have shown that the hydroxyl group of ortho-diphenol is the material basis of free radical scavenging activity. And the conjugated double bond at the C3 position has a synergistic effect.

2 Antidepressant effects

Rosmarinic acid has antidepressant effects in animal models of depression. Experiments were carried out on cell proliferation in the hippocampus of mice, and bromodeoxyuridine antibody was used for immunohistochemical analysis to explore its mechanism of action. It was found that in the rosmarinic acid treatment group, the labeled proliferative cells increased, combined with the forced swimming of the animal model of depression. Experiments have shown that rosmarinic acid proliferates and produces an antidepressant-like effect at least in part through the proliferation of new cells in the hippocampus.

3 The antibacterial effect of rosmarinic acid

Rosmarinic acid has broad-spectrum antimicrobial activity against both bacteria and fungi. Rosmarinic acid has obvious inhibitory effect on bacteria such as Bacillus subtilis, Bacillus luteus, Escherichia coli, Staphylococcus aureus and Rhizococcus solani. It has been scientifically found that rosmarinic acid can inhibit the growth and biofilm formation of Streptococcus caries and Streptococcus mutans, and reduce their glucosyltransferase activity, indicating that rosmarinic acid can be used for the prevention and treatment of oral diseases. Research on the antibacterial mechanism of rosmarinic acid shows that: on the one hand, rosmarinic acid can increase the permeability of bacterial cell membranes, resulting in a large amount of sugar and protein leakage, affecting the normal metabolism of bacteria; on the other hand, it can also affect bacterial protein It also inhibits Taq DNA polymerase. Rosmarinic acid has antibacterial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus, but Staphylococcus aureus is significantly more sensitive to rosmarinic acid than Escherichia coli.

(1) Inhibition of bacteria: Rosmarinic acid has a significant inhibitory effect on Bacillus subtilis, Luccinococcus and Escherichia coli.

(2) Inhibitory fungi: the inhibitory activity of rosmarinic acid on mycelial growth and spore germination of different phytopathogenic fungi.

(3) Inhibition of mold: Rosmarinic acid extracted from plants has an inhibitory effect on Phytophthora and its mold spores that cause soil-borne diseases, effectively reducing the germination of zoospores.

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